Characteristics of gastrointestinal hormones and inflammation levels in patients with IBS at different ages and their correlation with disease severity
10.3969/j.issn.1673-4130.2024.21.014
- VernacularTitle:不同年龄的IBS患者胃肠激素、炎症水平特征及其与疾病严重程度的相关性分析
- Author:
Shanshan GUO
1
;
Qiang LEI
;
Ping LU
Author Information
1. 新疆维吾尔自治区第一济困医院(自治区第四人民医院)内科,新疆乌鲁木齐 830017
- Keywords:
irritable bowel syndrome;
gastrointestinal hormones;
inflammatory markers;
disease se-verity
- From:
International Journal of Laboratory Medicine
2024;45(21):2632-2637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences in levels of serum gastrin(GAS)and gastric inhibitory peptide(GIP)in patients with irritable bowel syndrome(IBS)at different ages and their correlation with dis-ease severity.Methods A total of 108 patients with IBS who were treated in the hospital from February 2021 to March 2023 were selected as the research objects.IBS patients were divided into diarrhea type IBS group(n=60)and constipation type IBS group(n=48)according to their clinical types,and were divided into elder-ly group and non elderly group according to whether the patients were older than 60 years at enrollment.The severity of disease was assessed by the IBS Symptom Severity Scale(IBS-SSS).Serum gastrointestinal related hormones such as GAS,GIP,motilin(MTL)and 5-hydroxytryptamine(5-HT)were detected.Inflammatory markers such as interleukin(IL)-8,IL-10,IL-18 and calcitonin gene-related peptide(CGRP)were detected.Pearson correlation test was used to analyze the correlation between IBS-SSS and gastrointestinal related hor-mones and inflammatory markers.Multivariate Logistic regression analysis was used to screen the independ-ent risk factors of severe IBS.Results Among diarrhea type IBS patients and constipation type IBS patients,the mean IBS-SSS score in the non elderly group was significantly higher than that in the elderly group,and the proportion of patients with moderate IBS was higher than that in the elderly group,and the differences were statistically significant(P＜0.05).The mean levels of GAS and 5-HT in the non elderly group were sig-nificantly higher than those in the elderly group,and the differences were statistically significant(P＜0.05),but there were no significant differences in the levels of GIP and MTL between the two groups(P＞0.05).The mean levels of IL-18 and CGRP in the non elderly group were significantly higher than those in the elder-ly group,and the mean level of IL-10 in the non elderly group was significantly lower,and the differences were statistically significant(P＜0.05),but there was no significant difference in the level of IL-8 between the two groups(P＞0.05).Pearson correlation analysis showed that IBS-SSS scores were positively correlated with serum levels of 5-HT,IL-18 and CGRP in non-elderly IBS patients,elderly IBS patients and all enrolled IBS patients(P＜0.05).Multivariate Logistic regression analysis showed that the elevated serum levels of 5-HT,IL-18 and CGRP were independent risk factors for severe IBS in non-elderly patients(P＜0.05).Among all patients,only elevated serum 5-HT level was an independent risk factor for severe IBS(P＜0.05).Conclusion Regardless of the type of IBS,the severity of IBS in elderly patients is less than that in non-elderly patients.The levels of gastrointestinal hormones and inflammation markers are different in patients at different ages.The serum levels of 5-HT,IL-18 and CGRP are positively correlated with the severity of IBS,which are poten-tial biological indicators to reflect the severity of IBS.
