Relationship between serum S100A11,S100A14,CA125 and cytoreductive surgery outcomes in patients with stage Ⅱ B-Ⅳ epithelial ovarian cancer and their predictive value
10.3969/j.issn.1673-4130.2024.19.013
- VernacularTitle:血清S100A11、S100A14、CA125与ⅡB～Ⅳ期上皮性卵巢癌患者减瘤术结局的关系及其预测价值分析
- Author:
Hong LU
1
;
Yi YIN
;
Lingling LI
;
Yong LI
Author Information
1. 南通市肿瘤医院/南通大学附属肿瘤医院妇科,江苏南通 226300
- Keywords:
epithelial ovarian cancer;
cytoreductive surgery;
S100 calcium binding protein A11;
S100 calcium binding protein A14;
carbohydrate antigen 125
- From:
International Journal of Laboratory Medicine
2024;45(19):2372-2376,2381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum S100 calcium binding protein A(S100A)11,S100A14 and carbohydrate antigen 125(CA125)levels and the outcome of initial cytoreductive surgery in patients with stage Ⅱ B-Ⅳ epithelial ovarian cancer(EOC)and their predictive value.Methods A total of 124 patients with stage Ⅱ B-Ⅳ EOC who underwent initial cytoreductive surgery in the hospital from June 2018 to June 2021 were selected as the EOC group,70 patients with benign ovarian lesions were selected as the case control group,and 70 healthy people who underwent physical examination in the hospital during the same period were selected as the healthy control group.Serum levels of S100A11,S100A14 and CA125 were detected in each group.According to the outcome of cytoreductive surgery,EOC patients were divided in-to satisfactory group(70 cases)and unsatisfactory group(54 cases).The influencing factors of unsatisfactory surgical outcomes in patients with stage Ⅱ B-Ⅳ EOC were analyzed,and the clinical value of serum S100A11,S100A14 and CA125 in predicting unsatisfactory surgical outcomes in patients with stage Ⅱ B-ⅣEOC was evaluated.Results The serum levels of S100A11,S100A14 and CA125 in EOC group were higher than those in case control group and healthy control group(P＜0.05).The proportions of American Society of Anesthesiologists(ASA)grade Ⅲ,ascites,International Federation of Gynecology and Obstetrics(FIGO)stage ⅢC-Ⅳ and serum levels of CA125,S100A11 and S100A14 in unsatisfactory group were significantly higher than those in satisfactory group(P＜0.05).FIGO stage 111 C-Ⅳ and elevated serum levels of CA125,S100A11 and S100A14 were independent risk factors affecting the unsatisfactory outcome of cytoreductive surgery in patients with EOC(P＜0.05).The area under the curve(95％CI)of serum CA125,S100A11,S100A14 and the combination of the three to predict the unsatisfied outcome of EOC patients were 0.727(0.521-0.910),0.747(0.507-0.961),0.755(0.553-0.954)and 0.825(0.743-0.913),respectively.The predictive value of combined detection of CA125,S100A11 and S100A14 in predicting unsatisfactory outcome of cytoreductive surgery was better than that of serum CA125,S100A11 and S100A14 alone.Conclusion The el-evated serum levels of S100A11,S100A14 and CA125 in patients with stage ⅡB-Ⅳ EOC are associated with the unsatisfactory outcome of cytoreductive surgery.The combined detection of serum CA125,S100A11 and S100A14 has a high predictive value for the unsatisfactory outcome of cytoreductive surgery.
