Prognostic value of serum levels of HMGB1,IL-34 and ANGPTL4 in patients with acute respiratory distress syndrome
10.3969/j.issn.1673-4130.2024.16.020
- VernacularTitle:急性呼吸窘迫综合征患者血清HMGB1、IL-34、ANGPTL4水平对临床预后的预测价值
- Author:
Yongkang YANG
1
;
Junyi CHEN
;
Bo TANG
Author Information
1. 湖南省脑科医院/湖南省第二人民医院重症医学科,湖南长沙 410007
- Keywords:
acute respiratory distress syndrome;
high mobility group protein B1;
interleukin-34;
an-giopoietin-like protein 4;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(16):2028-2033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of serum levels of high mobility group protein B1(HMGB1),interleukin-34(IL-34)and angiopoietin like protein 4(ANGPTL4)in patients with acute respira-tory distress syndrome(ARDS).Methods A total of 97 patients with acute respiratory distress syndrome from June 2021 to June 2023 were selected as the observation group,and 97 healthy patients from the hospital during the same period were selected as the control group.The levels of HMGB1,IL-34 and ANGPTL4 were compared between the two groups.The clinical data and serum levels of HMGB1,IL-34 and ANGPTL4 of pa-tients with different prognosis were compared and analyzed,and the influencing factors of prognosis were ana-lyzed.The predictive value of prognostic factors on prognosis was analyzed,and the predictive value of serum HMGB1,IL-34 and ANGPTL4 combined detection on prognosis was evaluated.Results The serum levels of HMGB1,IL-34 and ANGPTL4 in observation group were higher than those in control group,with statistical significance(P＜0.05).Oxygenation index(PaO2/FiO2)in death group was lower than that in survival group,acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,Murray lung injury score(MLIS),HMGB1,IL-34 and ANGPTL4 levels were higher than those in survival group,and the differences were statistically significant(P＜0.05).PaO2/FiO2,APACHE Ⅱ score,MLIS,HMGB1,IL-34 and AN-GPTL4 levels were all prognostic factors of ARDS patients(P＜0.05).The area under the curve(AUC)of PaO2/FiO2,APACHE Ⅱ score,MLIS and HMGB1,IL-34 and ANGPTL4 for predicting prognosis were 0.779,0.799,0.808,0.844,0.772 and 0.822,respectively.There was no significant difference in AUC among prognostic factors(P＞0.05).The analysis of receiver operating characteristic curve showed that the AUC of se-rum HMGB1,IL-34 and ANGPTL4 combined to predict the prognosis of ARDS patients was 0.915(95％CI:0.841-0.962),which was significantly higher than that predicted by each indicator alone.Conclusion The combined detection of serum HMGB1,IL-34 and ANGPTL4 levels in ARDS patients has certain prognostic value.
