Effects of Taoren Honghua decoction combined with rehabilitation training on neurological function and serum MDA,bFGF,PTX3 levels in patients with cerebral ischemia-reperfusion injury
10.3969/j.issn.1673-4130.2024.16.016
- VernacularTitle:桃仁红花煎联合康复训练对脑缺血再灌注损伤患者神经功能及血清MDA、bFGF、PTX3水平的影响
- Author:
Pei YANG
1
;
Yuxiao ZHU
;
Nan LI
Author Information
1. 定州市人民医院康复医学科,河北定州 073000
- Keywords:
cerebral ischemia-reperfusion injury;
Taoren Honghua decoction;
rehabilitation training;
malondialdehyde
- From:
International Journal of Laboratory Medicine
2024;45(16):2005-2009
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Effects of Taoren Honghua decoction combined with rehabilitation training on neurological function and serum malondialdehyde(MDA),basic fibroblast growth factor(bFGF)and pentraxin 3(PTX3)levels in patients with cerebral ischemia-reperfusion injury(CIRI).Methods A total of 100 CIRI patients treated in Dingzhou People's Hospital from June 2020 to May 2023 as the study objects were randomly divided into treatment group(50 cases)and control group(50 cases).The control group was given routine treatment combined with rehabilitation training,and the treatment group was given Taoren Honghua decoction on the basis of the control group.The treatment effect,the score of National Institutes of Health Stroke Scale(NIHSS)and the score of Daily Living Ability Scale(ADL)before and after treatment were compared between the two groups,and the adverse reactions were recorded.Results The total effective rate of the treatment group[86.00％(43/50)]was significantly higher than that of the control group[68.00％(34/50)],and the difference was statistically significant(P＜0.05).Compared with before treat-ment,the NIHSS score of the treatment group and the control group was significantly decreased after treat-ment,and the ADL score was significantly increased,with statistical significance(P＜0.05).After treatment,compared with the control group,the NIHSS score in the treatment group was significantly decreased,and the ADL score was significantly increased,with statistical significance(P＜0.05).After treatment,compared with the control group,the levels of MDA and PTX3 in the treatment group were significantly decreased,while the levels of superoxide dismutase,bFGF,insulin-like growth factor 1 and vascular endothelial growth factor were significantly increased in the treatment group,with statistical significance(P＜0.05).The incidence of ad-verse reactions in the treatment group[12.00％(6/50)]was significantly lower than that in the control group[30.00％(15/50)],and the difference was statistically significant(P＜0.05).Conclusion Taoren Honghua Decoction combined with rehabilitation training has a good therapeutic effect on CIRI patients,and can im-prove the neurological function of patients.
