Clinical value of serum HDAC2 and HDAC6 levels combined with Doppler ultrasound indicators in diagnosing the occurrence of preeclampsia and fetal growth restriction in pregnant women
10.3969/j.issn.1673-4130.2024.14.008
- VernacularTitle:孕妇血清HDAC2、HDAC6水平联合多普勒超声指标诊断子痫前期和胎儿生长受限发生的临床价值
- Author:
Ling SUN
1
;
Hongxia FAN
;
Xiaomei SUN
Author Information
1. 河北省沧州中西医结合医院超声二科,河北沧州 061001
- Keywords:
histone deacetylase 2;
histone deacetylase 6;
preeclampsia;
fetal growth restriction;
ultrasound
- From:
International Journal of Laboratory Medicine
2024;45(14):1705-1709
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of serum histone deacetylase 2(HDAC2)and histone deacetylase 6(HDAC6)levels combined with Doppler ultrasound indicators in diagnosing the occurrence of preeclampsia(PE)and fetal growth restriction(FGR)in pregnant women.Methods A total of 176 PE and FGR pregnant women who underwent regular prenatal examination and delivered at Cangzhou Integrated Tra-ditional Chinese and Western Medicine Hospital from March 2021 to May 2023 were selected as the study sub-jects and separated into PE group(94 cases)and FGR group(82 cases),pregnant women with normal prena-tal examination results and delivery during the same period were selected as control group(91 cases).Enzyme linked immunosorbent assay was applied to detect the levels of serum HDAC2 and HDAC6,respectively.Doppler ultrasound was applied to detect resistance index(RI),pulsatile index(PI),and the ratio of maximum systolic and diastolic blood flow velocity of the umbilical artery(S/D).Receiver operating characteristic(ROC)curve was applied to analyze the clinical diagnostic value of Doppler ultrasound indicators(RI,PI,S/D)and HDAC2,HDAC6 for PE and FGR.Results The gestational age and spontaneous delivery rate in the PE and FGR groups were obviously lower than those in the control group(P＜0.05).The levels of serum HDAC2 and HDAC6 in the PE and FGR groups were obviously lower than those in the control group(P＜0.05).RI,PI,and S/D in the PE and FGR groups were obviously higher than those in the control group(P＜0.05).The area under the curve(AUC)of Doppler ultrasound indicators combined with serum HDAC2 and HDAC6 for diagnosing PE and FGR was 0.968 and 0.949,respectively,which was better than that of single detection(all P＜0.001).Conclusion The serum levels of HDAC2 and HDAC6 in pregnant women with PE and FGR are obviously reduced,and the combination of the two and Doppler ultrasound indicators has good di-agnostic value for the occurrence of PE and FGR.
