Exploration and application of age-specific cut-off values for anti-Müllerian hormone in the diagnosis of polycystic ovary syndrome
10.3969/j.issn.1673-4130.2024.10.020
- VernacularTitle:抗缪勒管激素诊断多囊卵巢综合征的年龄特异性阈值探讨及应用
- Author:
Qingfeng ZHOU
1
;
Min CAO
Author Information
1. 上海市松江区中心医院检验科,上海 201600
- Keywords:
anti-Müllerian hormone;
age-specific cut-off value;
generalized additive model;
polycys-tic ovary syndrome;
diagnosis performance
- From:
International Journal of Laboratory Medicine
2024;45(10):1248-1252
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the age-specific cut-off values and diagnostic efficacy of anti-Muller hormone(AMH)in the diagnosis of polycystic ovary syndrome(PCOS).Methods The Serum AMH levels were measured by immunofluorescence assay in 2 187 patients with menstrual disorders aged 14-40 years in the hospital.Patients who met the Rotterdam criteria were classified as the PCOS group,while those who did not were classified as the control group.The generalized additive model(GAMs)and the area under the re-ceiver operating characteristic(ROC)curve(AUC)were used to establish the age interval and the corre-sponding cut-off values of AMH.The efficacy of AMH in diagnosing PCOS in each age interval was evaluated and compared with the cut-off values provided by the reagent manufacturer.Results Based on GAMs model,the age cut-off values for AMH in predicting PCOS were 21,28,and 35 years old,respectively.The cut-off val-ues for the prediction of PCOS in the age categories of 14-＜20,20-＜28,28-＜35,and 35-40 years were 8.28,8.02,6.70,3.96 ng/mL.The AUC was 0.97(95％CI:0.93-0.99),0.97(95％CI:0.95-0.98),0.98(95％CI:0.95-0.98),and 0.99(95％CI:0.98-0.99),the sensitivity was 0.87,0.87,0.91,and 1.00,and the specificity was 0.94,0.93,0.90,and 0.93,respectively.In all age groups,AMH level in PCOS group was higher than that in control group,and the difference was statistically significant(P＜0.001).Conclusion Ap-plication of age-specific cut-off values of AMH could elegantly assess the value of AMH in discriminating P-COS patients in all age categories.
