Progress on biologic agents associated vasculitis

VernacularTitle:生物制剂相关性血管炎研究进展
Author: Xiaoling NIU ¹ ; Wenyan HUANG
Author Information

1. 上海市儿童医院　上海交通大学医学院附属儿童医院肾脏风湿免疫科　200062
Keywords: Children; Biologic agents; Drug induced vasculitis; Rheumatologic and immune diseases; Side effects
From: International Journal of Pediatrics 2024;51(8):518-522
CountryChina
Language:Chinese
Abstract: While biologic agents are widely used in rheumatology practice，its side effects become apparent and are brought into focus.Biologic agents associated vasculitis are drug induced vasculitis which are induced by biologic agents.It is one of the main and severe immunological side effects by biologic agents.Its pathogenesis is unclear.And the clinical characteristic is various.Tumor necrosis factor-α inhibitors are most likely to cause vasculitis，and leukocytoclastic vasculitis is the most common one.The diagnosis of biologicagents associated vasculitis is difficult and should be paid attention in clinical practice.The biologic agents withdrawal which induced vasculitis is the critical treatment，while steroids and immune-suppressants should be given if necessary.