Advances in the role of SOX family genes in male sex determination and male reproductive function
10.3760/cma.j.issn.1673-4408.2024.07.007
- VernacularTitle:SOX家族基因在男性性别决定及男性生殖功能中的作用研究进展
- Author:
Yijun TANG
1
;
Xiumin WANG
Author Information
1. 上海交通大学医学院附属上海儿童医学中心内分泌代谢科 200127
- Keywords:
SOX gene;
Sexual development;
Sex determination;
Testicular development
- From:
International Journal of Pediatrics
2024;51(7):457-460
- CountryChina
- Language:Chinese
-
Abstract:
Sex determination region of Y chromosome related HMG-box gene（SOX）was a group of related transcription factors with similar structures. In SOX family genes，SRY is the determinant gene of mammalian gonadal differentiation，which directly determines the direction of testis differentiation. SOX9 is an essential gene that initiates the development of testis during the process of sex differentiation. SOX8 and SOX2 also participate in sexual development and maintenance of male reproductive function. Similar to the SRY gene，these SOX family genes all have one high mobility group（HMG）domain. The product of HMG domain binds and bends specific target DNA. This article reviews the role of SOX family genes（SRY，SOX9，SOX8，SOX2）in male sex determination and male reproductive function.
