Progress on the treatment of neonatal hypoxic-ischemic encephalopathy with combination of therapeutic hypothermia and drugs
10.3760/cma.j.issn.1673-4408.2024.05.011
- VernacularTitle:亚低温联合药物治疗新生儿缺氧缺血性脑病的研究进展
- Author:
Xiaofang XU
1
;
Chunli LIU
;
Yayu ZHANG
Author Information
1. 内蒙古医科大学附属医院新生儿科,呼和浩特 010050
- Keywords:
Newborns;
Hypoxic-ischemic encephalopathy;
Therapeutic hypothermia;
Neuroprotective drugs
- From:
International Journal of Pediatrics
2024;51(5):335-340
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic-ischemic encephalopathy（HIE）is a neonatal brain injury disease caused by hypoxia and reduced cerebral blood flow due to perinatal asphyxia.Its incidence rate is quite high，and it is also one of the main factors leading to infant death. Effective treatment of HIE can reduce brain damage and improve the prognosis. In recent years，therapeutic hypothermia has been clinically recognized as an effective treatment for HIE，which can improve the survival rate of full-term infants with moderate to severe HIE and significantly reduce disability rates. However，the effective rate of the treatment is relatively low，with approximately 40% to 55% of children still facing moderate to severe neurodevelopmental sequela after therapeutic hypothermia.Therefore，a combination treament of HIE with neuroprotective drugs has been paid more attention.This treatment method further reduces the severity of hypoxic-ischemic brain injury，improves clinical symptoms，enhances neurological behavior，and alleviates neurodevelopmental disorders caused by hypoxic-ischemic brain injury，providing new ideas for exploring more neuroprotective therapies for HIE in the future.
