Progress on group 2 innate lymphoid cells in airway inflammation of asthma in children
10.3760/cma.j.issn.1673-4408.2024.05.001
- VernacularTitle:2型固有淋巴细胞参与儿童哮喘气道炎症的研究进展
- Author:
Siyu ZHU
1
;
Xiaoyan DONG
;
Ran ZHAO
Author Information
1. 上海交通大学医学院附属儿童医院 上海市儿童医院呼吸科 上海交通大学医学院儿童感染免疫与重症医学研究院 200062
- Keywords:
Children;
Group 2 innate lymphoid cells;
Asthma;
Airway inflammation;
Immunity;
Regulatory factor
- From:
International Journal of Pediatrics
2024;51(5):287-291
- CountryChina
- Language:Chinese
-
Abstract:
Group 2 innate lymphoid cells（ILC2s）are critical immune cells involved in airway inflammation in childhood bronchial asthma（hereinafter referred to as asthma）.Previous studies have demonstrated that over-activation of ILC2s is closely related to the pathogenesis of asthma and have identified a number of regulatory factors related to the immunomodulation of ILC2s，but the specific regulatory mechanism of ILC2s in asthma airway inflammation has not been clarified.The article will summarize the research progress on the pathogenesis and treatment of ILC2s and airway inflammation in childhood asthma.The summary of research progress on the relationship between ILC2s and airway inflammation can deepen the understanding of the pathogenesis of asthma and provide new ideas for the diagnosis and treatment of asthma.
