Silent information regulator 2 homolog 1 and bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2024.04.001
- VernacularTitle:沉默信息调节因子2相关酶1与支气管肺发育不良
- Author:
Chongbing YAN
1
;
Cheng CAI
Author Information
1. 上海交通大学医学院附属儿童医院 上海市儿童医院新生儿科 200062
- Keywords:
Bronchopulmonary dysplasia;
Silent information regulator 2 homolog 1;
Premature infant;
Pathogenesis
- From:
International Journal of Pediatrics
2024;51(4):215-219
- CountryChina
- Language:Chinese
-
Abstract:
Following the improvement of survival rate of very premature infants，the incidence of bronchopulmonary dysplasia（BPD）has been showing a rising trend in recent years.BPD is the most common and severe pulmonary complication in premature infants.Although prematurity and immature pulmonary growth are the most important risk factors in the development of BPD，the precise pathogenesis of BPD remains to be verified.Silent information regulator 2 homolog 1（SIRT1）belongs to sirtuin family，which plays an important role in the progress of inflammation，oxidative stress，apoptosis，autophagy and epithelial-mesenchymal transition，which is closely associated with BPD.Current studies of SIRT1 in the mechanism of BPD are reviewed in this article，which may provide reference for pathogenesis of BPD and potential therapeutic target.
