Semiconducting Polymer and Photosensitizer Co-Doping Polystyrene Microspheres for Afterglow Imaging of Microplastics in Vivo
10.19756/j.issn.0253-3820.241103
- VernacularTitle:半导体聚合物和光敏剂掺杂聚苯乙烯微球用于微塑料活体余辉成像示踪
- Author:
Ting-Jiao SHI
1
;
Li-Jian CHEN
;
Li-Xia YAN
;
Xu ZHAO
;
Xiu-Ping YAN
Author Information
1. 江南大学食品学院,分析食品安全学研究所,无锡 214122
- Keywords:
Microplastics;
Polystyrene microsphere;
Semiconducting polymers;
Afterglow imaging
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1517-1527
- CountryChina
- Language:Chinese
-
Abstract:
Microplastics pose a serious threat to the environment and human health,but the circulating distribution and transport processes of microplastics in organisms have not been fully assessed.Therefore,it is of great significance to construct a probe that can image trace microplastics and visually monitor their circulation and transport in vivo.Afterglow semiconducting polymers are attractive for applications in biological imaging as they do not contain heavy metal ions,are easy to biodegrade and allow high signal-to-noise ratio afterglow imaging without continuous excitation.In this study,with styrene as reaction monomer,polyvinylpyrrolidone as surfactant,and sodium persulfate as initiator,afterglow polystyrene microspheres for in vivo imaging of microplastics were prepared.During the polymerization process,poly[(9,9-di(2-ethylhexyl)-9H-fluo-rene-2,7-vinylene)-co-(1-methoxy-4-(2-ethylhexyloxy)-2,5-phenylenevinylene)](PF-MEHPPV)and photosensitizer silicon 2,3-naphthalocyanine bis(trihexylsilyloxide)(NCBS)were co-doped into polystyrene microspheres.The prepared afterglow polystyrene microspheres exhibited an afterglow duration of 96 h and a tissue penetration depth of 1.8 cm.It was found that co-doping of PF-MEHPPV and NCBS had little effect on the particle size and Zeta potential of the microspheres,and allowed to monitor the afterglow luminescence signal in vivo for 24 h.Imaging of mouse organs after anatomy showed that the afterglow signal was still observed in the stomach of mice 48 h after gavage.This study provided a new method for imaging and tracing microplastics in vivo.
