Extracellular Vesicle-Mediated Nucleic Acid Delivery and Its Application in Cancer Therapy
10.19756/j.issn.0253-3820.241258
- VernacularTitle:细胞外囊泡介导的核酸递送及其在癌症治疗中的应用
- Author:
Xiao-Zhen ZHAN
1
;
Qing-Yuan ZHANG
;
Hao-Nan DI
;
Xiao-Mei YAN
Author Information
1. 厦门大学化学化工学院化学生物学系,谱学分析与仪器教育部重点实验室,化学生物学福建省重点实验室,厦门 361005
- Keywords:
Extracellular vesicles;
Nucleic acid delivery;
Gene therapy;
Cancer therapy;
Nano-flow cytometry;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1390-1402
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles(EVs)are nano-sized membranous vesicles secreted and released by cells into the extracellular matrix.They carry bioactive molecules derived from parent cells and are regarded as media for intercellular communication and material transfer.Compared to synthetic nanocarriers,EVs possess lower immunogenicity,better biocompatibility,and enhanced ability to traverse biological barriers,making them ideal carriers for nucleic acid drug delivery.This article reviewed the loading technologies of EVs as carriers for nucleic acid drugs,with an in-depth analysis and discussion of the performance and application progress of endogenous and exogenous loading methods,strategies for evaluating nucleic acid loading quality,and the application of EV-mediated nucleic acid delivery in cancer therapy.Finally,the advantages and existing challenges of EVs as nucleic acid delivery vehicles in cancer treatment were summarized and their future development prospects in clinical applications was anticipated.
