Rapid Detection of Fentanyl by Electrochemical Sensor Based on Fe/Ni Binary Metal-Organic Frameworks/Multi-Walled Carbon Nanotubes
10.19756/j.issn.0253-3820.231417
- VernacularTitle:基于Fe/Ni二元金属有机框架/多壁碳纳米管的电化学传感器对芬太尼的快速检测
- Author:
Zhi-Dong ZHAO
1
;
Yuan HE
;
Xing-Rui QI
;
Tao JIN
Author Information
1. 中国科学院广州化学研究所,中国科学院特种精细化学品工程实验室,广州 510650;中国科学院大学,北京 101408;贵州警察学院侦查系,贵州省高校风险防控研究中心,贵阳 550005
- Keywords:
Fentanyl;
MIL-88B(Fe/Ni);
Multi-walled carbon nanotubes;
Electrochemical detection;
Differential pulse voltammetry
- From:
Chinese Journal of Analytical Chemistry
2024;52(8):1152-1162
- CountryChina
- Language:Chinese
-
Abstract:
As a potent narcotic opioid analgesic,fentanyl has been used as intravenous anesthesia for clinical procedures while also being abused by drug users,resulting in an increasing number of deaths year by year,and thus it is urgent to develop rapid screening methods for fentanyl.In this study,by using a binary metal-organic framework MIL-88B(Fe/Ni)as an electrocatalyst,an electrochemical sensor based on multi-walled carbon nanotubes(MWCNTs)modified glassy carbon electrode(GCE)was constructed for rapid detection of fentanyl.The morphology,crystal structure and elemental characteristics of the synthesized MIL-88B(Fe/Ni)/MWCNTs and MIL-88B(Fe/Ni)composites were confirmed by scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).In addition,the electrochemical characterization also revealed that the synthesized MIL-88B(Fe/Ni)/MWCNTs composites modified GCE possessed low electrochemical impedance and large electrochemical surface area with ultra-high sensitivity to fentanyl.The experimental conditions for the electrochemical detection of fentanyl were optimized and the limit of detection(LOD,3Sb/M)for fentanyl was 0.015 μmol/L with a linear range of 0.04-10 μmol/L,and the reproducibility,selectivity and stability were all favorable.In addition,the developed sensor showed satisfactory performance in real samples,with recoveries ranging from 58.6%to 81.5%and from 82.7%to 97.5%in urine and blood,respectively,at concentration levels of 0.2-1.0 μmol/L.The proposed MIL-88B(Fe/Ni)/MWCNTs composite could be used as a novel electrode material for electrochemical detection of fentanyl,and had great potential for rapid detection of fentanyl in public security anti-drug or medical emergency.
