Target Screening and Preliminary Risk Assessment of 63 Kinds of Chemical Hazardous Substances in Face Masks
10.19756/j.issn.0253-3820.241166
- VernacularTitle:口罩中63种化学危害物质的靶向筛查及风险评估
- Author:
Xian-Shuang MENG
1
;
Yi-Jing LIU
;
Xing-Zhou GUO
;
Qing ZHANG
;
Qiang MA
Author Information
1. 中国检验检疫科学研究院,北京 100176
- Keywords:
High-resolution mass spectrometry;
Targeted screening;
Face masks;
Chemical hazardous substances;
Risk assessment
- From:
Chinese Journal of Analytical Chemistry
2024;52(7):1004-1011,中插35-中插52
- CountryChina
- Language:Chinese
-
Abstract:
A target screening methodology was developed for detection of 63 kinds of chemical hazards substances,including 17 kinds of flame retardants,14 kinds of perfluorinated compounds,15 kinds of phthalate esters,5 kinds of fluorescent whitening agents and 12 kinds of ultraviolet absorbers,in various types of face masks using ultra high performance liquid chromatography-quadrupole-orbitrap high-resolution mass spectrometry based on an in-house database and mass spectral library.And the quantification was achieved using the external standard method.The results showed that the linear correlation coefficient(r)of all compounds was greater than 0.99,the limits of detection(LODs)ranged from 3.3 to 26.7 μg/kg(S/N=3),the limits of quantification(LOQs)ranged from 10.0 to 80.0 μg/kg(S/N=10),the average recoveries(n=6)were 72.3%-102.6%,and the relative standard deviations(RSDs)were 0.8%-9.9%.The validation of the screening results from both the database and mass spectral library was conducted,and benzophenone and dibutyl phthalate were detected from three positive samples.The human health exposure assessment of the inhalation exposure doses based on the relevant exposure models showed that the contents of benzophenone and dibutyl phthalate were within the recommended reference doses.The method represented a valuable technical reference for ensuring the quality and safety of face mask products and protecting consumer health.
