Research Progress of Biomimetic Imprinting Affinity Analysis Technique
10.19756/j.issn.0253-3820.231273
- VernacularTitle:仿生印迹亲和分析技术研究进展
- Author:
Zhao-Zhou LI
1
;
Yu-Hua WEI
;
Xiao-Chong ZHANG
;
Xiu-Jin CHEN
;
Yao WANG
;
Hua-Wei NIU
;
Fang LI
;
Hong-Li GAO
;
Hui-Chun YU
;
Yun-Xia YUAN
Author Information
1. 河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,洛阳471000
- Keywords:
Molecularly imprinted;
Biomimetic technology;
Affinity analysis;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(6):763-777
- CountryChina
- Language:Chinese
-
Abstract:
Molecular imprinting is a biomimetic technique that simulates the specific recognition of biological macromolecules such as antibody. Based on molecular imprinting and high-specificity affinity analysis,the biomimetic imprinting affinity analysis (BIA) possesses many advantages such as high sensitivity,strong tolerance,good specificity and low cost,and thus,it has shown excellent prospects in food safety detection,pharmaceutical analysis and environmental pollution monitoring. In this review,the construction methods of recognition interfaces for BIA were summarized,including bulk polymerization,electro-polymerization and surface molecular imprinting. The application of molecularly imprinted polymers in different analysis methods,such as radiolabeled affinity analysis,enzyme-labeled affinity analysis,fluorescence-labeled affinity analysis,chemiluminescence affinity analysis and electrochemical immunosensor was mainly discussed. Furthermore,the challenges and future development trends of BIA in practical application were elucidated. This review might provide new reference ideas and technical supports for the further development of BIA technique.
