Role of sex-determining region Y-related high-mobility group box 11 in differentiation,development and regeneration of central nervous system
10.16781/j.CN31-2187/R.20210617
- VernacularTitle:性别决定区Y相关高迁移率族盒蛋白11在中枢神经系统分化、发育与再生中的作用
- Author:
Xiaoxiang HOU
1
;
Chunhui WANG
;
Junyu WANG
;
Danfeng ZHANG
Author Information
1. 海军军医大学(第二军医大学)第二附属医院神经外科,全军神经外科研究所,上海市神经外科研究所,上海 200003
- Keywords:
sex-determining region Y-related high-mobility group box 11;
central nervous system;
differentiation;
development;
regeneration
- From:
Academic Journal of Naval Medical University
2024;45(11):1408-1413
- CountryChina
- Language:Chinese
-
Abstract:
Sex-determining region Y-related high-mobility group box 11(SOX11)was initially considered as one of the trans-acting factors supporting the differentiation of stem cells and the survival of neural precursors.However,in recent studies,it was found that SOX11 played an important role in the transcriptional regulation of the development,shaping and regeneration of neurons,and it was expected to be a target for the regeneration of injured nerves.This article reviews the physiological and pathophysiological functions of SOX11 in the central nervous system and its role in nerve regeneration.
