Correlation between peripheral arterial plaques and coagulation function in patients with type 2 diabetes mellitus
10.16781/j.CN31-2187/R.20240190
- VernacularTitle:2型糖尿病合并外周动脉斑块与凝血功能的相关性
- Author:
Ben CHEN
1
;
Jin LU
Author Information
1. 海军军医大学(第二军医大学)第一附属医院内分泌科,上海 200433
- Keywords:
type 2 diabetes mellitus;
carotid arterial plaque;
lower extremity arterial plaque;
fibrinogen
- From:
Academic Journal of Naval Medical University
2024;45(9):1174-1179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between coagulation function and peripheral arterial plaques in patients with type 2 diabetes mellitus. Methods A total of 269 patients with type 2 diabetes mellitus who were hospitalized in Department of Endocrinology of our hospital from May to Aug. 2022 were enrolled and divided into carotid plaque group (131 cases) and non-carotid plaque group (138 cases),or lower extremity arterial plaque group (134 cases) and non-lower extremity arterial plaque group (135 cases). General data and coagulation function indexes of the patients between groups were compared. Independent influencing factors of type 2 diabetes mellitus complicated with peripheral arterial plaques were evaluated using logistic regression analysis. Results Compared with the non-carotid plaque group,the fibrinogen level was significantly higher in the carotid plaque group (3.15[2.79,3.79]g/L vs 2.99[2.66,3.42]g/L,P=0.005). Logistic regression analysis showed that fibrinogen was an independent risk factor of carotid plaque in type 2 diabetes mellitus patients (odds ratio=1.338,95％ confidence interval 1.061-2.078,P<0.05). There was no significant difference in coagulation function indexes between the lower extremity arterial plaque and non-lower extremity arterial plaque groups (all P>0.05). Conclusion There are different correlations between peripheral arterial plaques in different parts and coagulation function in type 2 diabetes mellitus patients;those with carotid plaque have higher fibrinogen level,and fibrinogen is an independent risk factor for carotid plaque after controlling other confounding factors;however,there is no correlation between lower extremity arterial plaque and coagulation function indexes.
