Study progress on ferroptosis in endometriosis
10.3969/j.issn.1671-8348.2024.21.022
- VernacularTitle:铁死亡在子宫内膜异位症中的研究进展
- Author:
Zhuo LI
1
;
Hua ZHOU
;
Weiwei ZENG
Author Information
1. 上海中医药大学附属曙光医院妇科,上海 210213;上海市浦东新区高东社区卫生服务中心中医科,上海 201208
- Keywords:
ferroptosis;
endometriosis;
iron metabolism;
infertility;
review
- From:
Chongqing Medicine
2024;53(21):3318-3322,3328
- CountryChina
- Language:Chinese
-
Abstract:
Endometriosis(EMs)as a common chronic disease affects nearly 10％of childbearing age women,may cause other complications such as infertility,moreover has a tendency to develop malignant tumors.Ferroptosis is a newly discovered programmed cell death,its main characteristic is manifested by in-tracellular free ferrous excessively mediating Fenton reaction and eventually leads to lipid peroxidation in the cell membrane,thus causes the cell death.The overall manifestation of EMs lesions is iron death resistance,which is related with the iron overload and oxidative stress.The abnormal changes of intracellular iron concen-tration may lead to the accumulation of reactive oxygen and imbalance of redox homeostasis,thus leading to the occurrence of ferroptosis.At present,the pathogenesis and effect of ferroptosis on EMs are not completely clear,and the study on its physiological and pathological mechanism is very important for its diagnosis and treatment.This article reviews the research progress of the occurrence and development of EMs with ferropto-sis as the starting point in order to provide the new ideas for the pathogenesis,diagnosis and treatment of EMs.
