Nutritional status of vitamin D in children patients with inflammatory bowel disease:a meta analysis
10.3969/j.issn.1671-8348.2024.20.016
- VernacularTitle:炎症性肠病患儿维生素D营养状况的meta分析
- Author:
Yan XUE
1
;
Weiran LI
;
Ping WANG
;
Li XU
Author Information
1. 天津市儿童医院/天津大学儿童医院/天津市儿科研究所,天津 300134;天津市儿童出生缺陷防治重点实验室,天津 300134
- Keywords:
children;
inflammatory bowel disease;
25-hydroxyvitamin D;
nutritional status;
meta analy-sis
- From:
Chongqing Medicine
2024;53(20):3132-3137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and clinical significance of 25-hydroxyvitamin D[25(OH)D]in children patients with inflammatory bowel disease(IBD).Methods The relevant articles on ser-um 25(OH)D in children patients with IBD as the study subjects in the databases of CNKI,Wanfang,PubMed,Embase and Cochrane Library were retrieved from the database establishment to April 22,2024.The RevMan5.4 software was used to conduct the meta analysis on the literatures meeting the conditions.The differences in serum 25(OH)D levels between children with IBD and control group,children patients with ac-tive/remission stage and control group,children patients with active stage and remission stage were analyzed.Results Ten studies were included with a total of 902 children patients with IBD and 893 healthy children.The meta analysis results showed that compared with the age-matched healthy children,the deficiency rate of serum 25(OH)D in children patients with IBD had no significant difference(RR=1.28,95％CI:0.71-2.33,P=0.41),but serum 25(OH)D level was significantly lower(MD=-2.88,95％CI:-5.69 to-0.07,P=0.04),both in the active stage and remission stage(active stage:MD=-7.40,95％CI:-11.25 to-3.55,P＜0.001;remission stage:MD=-2.59,95％CI:-3.17 to-2.01,P＜0.001).Moreover,compared with the IBD remission stage,the serum 25(OH)D level in active stage of the children patients with IBD was signif-icantly decreased(MD=-4.11,95％CI:-5.56 to-2.67,P＜0.001).Conclusion Clinic should pay high attention to the comprehensive prevention and treatment of vitamin D deficiency in children patients with IBD.
