Research progress on potential mechanism of moxibustion restoring circadian rhythm mediated macrophage circadian rhythm in treatment of RA immunosenescence
10.3969/j.issn.1671-8348.2024.19.024
- VernacularTitle:艾灸整复生物钟介导的巨噬细胞昼夜节律治疗RA免疫衰老的潜在机制研究进展
- Author:
Liu HE
1
;
Haiyan ZHOU
;
Yumei ZHONG
Author Information
1. 成都市第一人民医院/成都中医药大学附属中西医结合医院,成都 610041
- Keywords:
biological clock;
macrophages;
immunosenescence;
moxibustion;
rheumatoid arthritis;
re-view
- From:
Chongqing Medicine
2024;53(19):3013-3017
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic synovial in-flammation.Moxibustion treatment can significantly improve RA immune disorders and reduce synovial in-flammation,but its mechanism of action needs to be further deepened.Senescence is a key factor that induces the occurrence and development of RA,and macrophages,as the key sentinel sites of the immune system to monitor aging,play an important role in the onset process of RA.The circadian clock dominates the circadian rhythm of the body,regulates the expression of a variety of proteins and cell functions,and is widely involved in the physiological and pathological processes of a variety of diseases.The circadian clock is involved in mac-rophage senescence and has the effect of regulating immune disorders.Among the mechanisms affecting the occurrence and development of RA,macrophage senescence has received more and more attentions as an im-portant breakthrough point.Therefore,this article mainly elucidates the possible pathogenesis of RA from the perspective of the involvement of the biological clock in macrophage senescence and analyzes the feasibility of moxi-bustion in the treatment of RA by regulating the biological clock and participating in macrophage senescence.
