Research progress on action mechanism of sodium butyrate in apoptosis of colorectal cancer cells
10.3969/j.issn.1671-8348.2024.16.025
- VernacularTitle:丁酸钠在结直肠癌细胞凋亡中的作用机制研究进展
- Author:
Shunli LUO
1
;
Suxia SUN
Author Information
1. 湖南医药学院公共卫生与检验医学院,湖南怀化 418000
- Keywords:
sodium butyrate;
colorectal cancer;
cell apoptosis;
mechanism;
review
- From:
Chongqing Medicine
2024;53(16):2530-2535,2542
- CountryChina
- Language:Chinese
-
Abstract:
Sodium butyrate is a sodium salt of four-carbon short chain fatty acids produced by dietary fiber under the action of intestinal microorganisms,it can provide energy for intestinal epithelial cells,and plays an important role in maintaining the integrity of intestinal epithelial cells,inhibiting intestinal inflamma-tion and tumor.In recent years,many studies have indicated that sodium butyrate can mediate apoptosis of colorectal cancer cells by inhibiting histone deacetylase activity,cysteine protease mediation and endoplastic re-ticulum (ER) stress,suggesting that sodium butyrate may be a potential anti-colorectal cancer drug.This arti-cle aims to review the advance progress in the role and mechanism of sodium butyrate in colorectal cancer cell apoptosis,and briefly describe the relationship between sodium butyrate in maintaining intestinal microenvi-ronment and enhancing the immune barrier function of intestinal mucosa with inhibiting intestinal inflamma-tion in order to provide reference for the development of sodium butyrate as first-line anti-colorectal cancer drugs.
