Analysis on risk factors of antibiotic related diarrhea occurrence in elderly patients with acute exacerbation of COPD treated by non-invasive ventilator
10.3969/j.issn.1671-8348.2024.16.011
- VernacularTitle:无创呼吸机治疗COPD急性加重期老年患者发生抗生素相关腹泻的危险因素分析
- Author:
Qianbao ZHANG
1
;
Bin SHI
;
Xiaoyu WANG
;
Wei SHEN
;
Xing LIU
Author Information
1. 南京鼓楼医院集团宿迁医院呼吸与危重症医学科,江苏宿迁 223800
- Keywords:
non-invasive ventilator;
COPD acute exacerbation stage;
antibiotic related diarrhea;
risk factor
- From:
Chongqing Medicine
2024;53(16):2458-2461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of antibiotic related diarrhea occurrence in elderly pa-tients with acute exacerbation of chronic obstructive pulmonary disease (COPD) treated by non-invasive vent-ilator.Methods The clinical data of 248 elderly patients with acute exacerbation of COPD treated in this hos-pital from June 2020 to June 2023 were analyzed retrospectively.The univariate and multivariate logistic re-gression were used to analyze the influencing factors for the patients with antibiotic related diarrhea occur-rence.Results Among 248 elderly patients with acute exacerbation of COPD,49 cases (19.76％) developed antibiotic related diarrhea.The results of univariate and multivariate logistic regression analysis showed that the age≥70 years old,non-invasive ventilator treatment time≥7 d,broad-spectrum antibiotics use,antibiotic treatment time≥7 d,hospitalization duration≥10 d and severe illness condition were the risk factors for anti-biotic related diarrhea occurrence in the elderly patients with acute exacerbation of COPD (P<0.05),while the daily disinfection of ventilator tubes and masks was a protective factor (P<0.05).Conclusion The inci-dence rate of antibiotic-related diarrhea in the elderly patients with acute exacerbation of COPD treated by non-invasive ventilator is high,which is closely related to the age of patients,ventilation time,ventilator pipe-line and mask disinfection,antibiotic use time,whether using broad-spectrum antibiotics,hospitalization dura-tion and severity of disease condition.
