Study on treatment course of determining caffeine for treating apnea of prematurity with oxygen discontinuation as target orientation
10.3969/j.issn.1671-8348.2024.15.016
- VernacularTitle:以停氧为目标导向确定咖啡因治疗早产儿呼吸暂停的疗程研究
- Author:
Jianhui WANG
1
;
Wenhui DONG
;
Ying FAN
;
Lihong RAN
;
Yuan SHI
Author Information
1. 重庆医科大学附属儿童医院新生儿科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室,重庆 400014;儿童感染与免疫罕见病重庆市重点实验室,重庆 400014
- Keywords:
apnea of prematurity;
caffeine;
oxygen dependence;
hospitalization duration;
bronchopulmo-nary dysplasia
- From:
Chongqing Medicine
2024;53(15):2334-2338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical benefit of caffeine treatment regimen determined based on oxygen discontinuation as target orientation for oxygen-dependent preterm infants.Methods A total of 219 preterm infants admitted to the neonatal department of this hospital from October 2021 to September 2023 were selected and divided into the intervention group (caffeine treatment targeting weaning oxygen,n=108) and the control group (routine caffeine treatment,n=111).The differences in the apnea recurrence,reuse of caffeine,time of caffeine discontinuation,duration of using oxygen and hospitalization duration were compared between the two groups.Results Compared with the control group,the correcting fetal age by stopping caffe-ine in the intervention group was greater[(35.9±1.7)weeks vs.(34.4±1.5)weeks],hospitalization dura-tion was longer[(64.62±20.60)d vs.(57.96±17.68)d],and the differences were statistically significant (P<0.05).The apnea recurrence rate,reuse rate of caffeine,duration of oxygen use,incidence rate of moder-ate to severe bronchopulmonary dysplasia,mechanical ventilation use rate,hospitalization expenses,≥grade Ⅱ necrotizing enterocolitis,feeding intolerance,tachycardia incidence rate and body weight increase velocity had no statistical differences between the two groups (P>0.05).Conclusion Determining the caffeine treatment course regimen by oxygen discontinuation as target orientation could not reduce the recurrent risk of preterm infants apnea recurrence risk,which could prolong the hospitalization duration.
