Clinical effect of Sijunzi decoction combined with Fangji Huangqi decoction added and decreased in treating chronic heart failure patients with reduced ejection fraction and Qi deficiency,blood stasis and phlegm retention syndrome
10.3969/j.issn.1671-8348.2024.14.017
- VernacularTitle:四君子汤合防己黄芪汤加减治疗射血分数降低慢性心力衰竭气虚血瘀痰饮证患者的临床疗效
- Author:
Jie LIU
1
;
Chunling LIANG
;
Xiaojie CHEN
;
Ning LI
;
Yuanyuan HUANG
Author Information
1. 中国中医科学院望京医院急诊内科,北京 100102
- Keywords:
ejection fraction;
chronic heart failure;
syndrome of Qi deficiency,blood stasis and phlegm retention;
Sijunzi decoction and Fangji Huangqi decoction;
Sacubitril Valsartan Sodium Tablets;
systolic blood pressure;
left ventricular remodeling
- From:
Chongqing Medicine
2024;53(14):2168-2172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of Sijunzi decoction and Fangji Huangqi decoction combined with Sacubitril Valsartan Sodium Tablets in treating chronic heart failure patients with reduced ejec-tion fraction and Qi deficiency,blood stasis and phlegm retention.Methods Ninety-four inpatients with chro-nic heart failure treated in this hospital from January 2021 to December 2022 were selected as the study sub-jects and divided into the Sijunzi Decoction and Fangji Huangqi Decoction combined with Sacubitril Valsartan Sodium Tablets group (the Chinese medicine combined group) and Sacubitril Valsartan Sodium Tablets group (the control group) according to the random number table method.Both groups were treated with standard therapy,and the Chinese medicine combined group added Sijunzi Decoction and Fangji Huangqi Decoction on this basis.Both groups were continuously treated for 8 weeks.The mean systolic blood pressure,left ventricu-lar end diastolic diameter (LVEDD),left ventricular ejection fraction (LVEF),TCM syndrome score and 6 min walking test (6-MWT) results at 24 h before treatment and after treatment were compared between the two groups.Results The average 24 h systolic blood pressure,score of each TCM syndrome and LVEDD after treatment in the two groups were decreased compared with those before treatment (P<0.05),while LVEF and 6-MWT in the two groups were increased,and the differences were statistically significant (P<0.05). Compared with the control group,the average 24 h systolic blood pressure in the Chinese medicine combined group was higher,each score of TCM syndrome score and LVEDD were lower,LVEF and 6-MWT were high-er,and the differences were statistically significant (P<0.05).Conclusion Sijunzi Decoction and Fangji Huangqi Decoction combined with Sacubitril Valsartan Sodium Tablets has a good effect on the patients with chronic heart failure with reduced ejection fraction and Qi deficiency,blood stasis and phlegm retention,which could effectively increase the systolic blood pressure,improve the cardiac coronary arterial perfusion and the quality of life of the patients,and alleviate the left ventricular remodeling status.
