Analysis on diagnostic efficiency of interleukin 27,adenosine deaminase and γ-interferon in tuberculous pleurisy
10.3969/j.issn.1671-8348.2024.08.003
- VernacularTitle:白细胞介素27、腺苷脱氨酶和γ-干扰素对结核性胸膜炎的诊断效能分析
- Author:
Chaojie ZHOU
1
;
Jun YUE
Author Information
1. 同济大学附属上海市肺科医院检验科,上海 200433
- Keywords:
tuberculous pleurisy;
pleural effusion;
interleukin 27;
adenosine deaminase;
interferon-γ
- From:
Chongqing Medicine
2024;53(8):1132-1136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic efficiency of interleukin-27 (IL-27),adenosine de-aminase (ADA) and interferon-γ (IFN-γ) in tuberculous pleurisy (TBP).Methods The pleural effusion sam-ples in 315 cases visiting in this hospital from May 2022 to May 2023 were collected.Among them,165 cases diagnosed as TBP were included in the TBP group,and the other 150 samples were included in the control group (mainly malignant pleural effusion).The levels of IL-27,ADA and IFN-γ in pleural effusion were detec-ted.The receiver operating characteristic (ROC) curve was drawn,and the sensitivity and specificity of each indicator alone and combined diagnosis were evaluated by the area under the ROC curve (AUC).Results The levels of IL-27,ADA and IFN-γ in the TBP group were higher than those in the control group (P<0.05). The AUC value of single indicator in diagnosing TBP all exceeded 0.85,in which AUC of ADA for diagnosing TBP was maximal (0.92),when its optimal cutoff value was 22.48 U/L,the sensitivity and specificity of diag-nosis were 80.61％ and 93.33％,respectively,when the combined diagnosis,the diagnostic efficiency of IL-27 and IFN-γ combination was optimal,the AUC value was 0.94,the sensitivity and specificity were 89.70％ and 93.33％ respectively.Conclusion The single indicator of IL-27,ADA and IFN-γ has the higher diagnostic ef-ficiency for TBP,but the combination diagnosis of IL-27 and IFN-γ has more advantages.
