Progress of pathology and genetics of histologic transformation in follicular lymphoma

VernacularTitle:滤泡淋巴瘤组织学转化的病理及遗传学研究进展
Author: Junhong ZHUO ¹ ; Wenyi LU ; Zunmin ZHU
Author Information

1. 河南省人民医院血液科　郑州大学人民医院　河南省人民医院血液病研究所，郑州　450003
Keywords: Lymphoma, follicular; Genetics; Biomarker; Histologic transformation
From: Journal of Leukemia & Lymphoma 2024;33(11):696-700
CountryChina
Language:Chinese
Abstract: Follicular lymphoma (FL) is an indolent lymphoma derived from B cells, and most patients have a good prognosis, high remission rate and long overall survival. However, approximately 2%-3% of FL patients develop aggressive lymphoma during treatment or surveillance each year. Transformed FL has high heterogeneity and poor prognosis, and may be involved in clonal evolution by a variety of molecular mechanisms such as bcl-2 mutation, myc mutation, histone modification genes mutation, CDKN2A/B deletion and disruptions in the tumor microenvironment. At present, there are no standard biomarkers available to predict the transformation and prognosis. In this paper, the pathological characteristics, gene mutation and tumor microenvironment of FL histologic transformation are reviewed.