Progress of the role of autophagy in acute lymphoblastic leukemia
10.3760/cma.j.cn115356-20230601-00122
- VernacularTitle:自噬在急性淋巴细胞白血病中作用的研究进展
- Author:
Yaocan CHEN
1
;
Xiaoqing LIAO
;
Jinyan WU
;
Xuanzhu LIU
;
Jing HU
Author Information
1. 重庆医科大学检验医学院，重庆 400016
- Keywords:
Autophagy;
Leukemia, lymphoblastic, acute;
Treatment;
Apoptosis;
Drug resistance
- From:
Journal of Leukemia & Lymphoma
2024;33(9):573-576
- CountryChina
- Language:Chinese
-
Abstract:
As a malignant hematological disease mainly originating from T or B lymphoid progenitor cell, acute lymphocytic leukemia (ALL) is more prevalent in children. With the gradual revelation of the autophagy mechanism, the role of autophagy in ALL has gained increasing attention. Autophagy can not only stimulate the survival of leukemia cells as an adaptive response, but also inhibit cell proliferation in some other cases. Therefore, how to regulate autophagy in promoting death or survival and reduce the drug resistance in ALL has become a hotspot. This article reviews the role of autophagy in ALL.
