Progress of molecular mechanisms and targeted therapies of aberrant histone modifications targeting the immune microenvironment of B-cell lymphoma
10.3760/cma.j.cn115356-20221201-00343
- VernacularTitle:组蛋白修饰异常靶向免疫微环境促进B细胞淋巴瘤发生和发展的分子机制及靶向治疗进展
- Author:
Xiang LI
1
;
Mengmeng JI
;
Weili ZHAO
Author Information
1. 上海交通大学医学院附属瑞金医院 国家转化医学中心 医学基因组学国家重点实验室 上海血液学研究所，上海 200025
- Keywords:
Lymphoma, large B-cell, diffuse;
Histone modification;
Immunosuppressive microenvironment;
Molecular targeted therapy
- From:
Journal of Leukemia & Lymphoma
2024;33(5):309-313
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal histone modifications, mainly including abnormal histone methylation and acetylation, play a crucial role in the pathogenesis of B-cell lymphoma. Recent studies have shown that abnormal histone modifications can promote the development of lymphoma by creating a tumor supportive immune microenvironment to promote tumor proliferation and immune escape. Therefore, drugs targeting histone modification gene abnormalities are currently a hot field of B-cell lymphoma. This article reviews the immune microenvironment of B-cell lymphoma, histone modification abnormalities targeting the immune microenvironment, immunomicrobial alterations, and advances in related targeted therapeutic agents.
