IgE production from the nasal polyp tissue: comparison between atopic and non-atopic subjects.
- Author:
Hee Yeon KIM
1
;
Dong Ho NAHM
;
Kyung Sik SUH
;
Hae Sim PARK
Author Information
1. Department of Allergy, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Clinical trial ; Comparative Study ; Randomized Controlled Trial
- MeSH:
Albumins/analysis;
Antibodies, Anti-Idiotypic/analysis*;
Biopsy, Needle;
Comparative Study;
Enzyme-Linked Immunosorbent Assay;
Female;
Human;
Hypersensitivity, Immediate/immunology*;
IgE/biosynthesis*;
IgE/analysis;
Male;
Nasal Polyps/pathology;
Nasal Polyps/immunology*;
Radioimmunoassay;
Reference Values;
Tissue Culture;
Substances: IgE;
Substances: Antibodies, Anti-Idiotypic;
Substances: Albumins
- From:The Korean Journal of Internal Medicine
1998;13(2):83-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES AND METHODS: To confirm the local production of IgE antibody from the nasal polyp tissue, and to evaluate the difference between atopics and non-atopics, nasal polyp tissues were taken from both 10 atopic and 10 non-atopic subjects. The tissue total IgE (tlgE) level was measured by enzyme-linked immunosorbent assay (ELISA) and serum tlgE level by radio-immunoassay. The tissue albumin level was measured by nephelometry, and serum albumin level by Bromocresol green method. RESULTS: The polyp tissue tlgE/albumin as well as serum tlgE/albumin ratio were significantly higher in atopics than in non-atopics (p < 0.05), with no difference in the albumin level between the two groups (p > 0.05). Three non-atopic subjects had high polyp tissue tlgE/albumin (> 10). A significant correlation was noted between serum tlgE/albumin and polyp tlgE/albumin (r = 0.46, p = 0.04). The ratio of polyp tlgE/albumin to serum tlgE/albumin was greater than 1 in all of the non-atopic subjects and 7 of 10 atopic subjects. CONCLUSION: These findings support the hypothesis that IgE antibody could be locally produced from the nasal polyp tissue of non-atopic subjects as well as atopic subjects. The possibility of an isolated local production of IgE antibody was suggested.
