COVID-19 in children: epidemic issues and candidate vaccines
10.1097/CM9.0000000000002169
- VernacularTitle:COVID-19 in children: epidemic issues and candidate vaccines
- Author:
Peng ZHANG
1
;
Mingwei WEI
;
Pengfei JIN
;
Zhuopei LI
;
Jingxin LI
;
Fengcai ZHU
Author Information
1. Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210009, China
- Keywords:
Adverse events;
COVID-19;
Children;
COVID-19 vaccine;
SARS-CoV-2 transmission;
Vaccine safety
- From:
Chinese Medical Journal
2022;135(11):1314-1324
- CountryChina
- Language:Chinese
-
Abstract:
A large-scale vaccination of coronavirus disease-19 (COVID-19) in adults has been conducted for nearly a year, and there is a growing recognition that immunization for children is also essential. It has been months since emergency use of pediatric COVID-19 vaccine was approved, we reviewed the prevalence and transmission of COVID-19 in children. The prevalence of COVID-19 in children is reduced due to vaccination even in a Delta prevalent period, so an increase in the vaccination rate is needed in children. Although the precise role of children in the transmission requires more research to uncover, they likely played a significant role, according to the available literature. We also described four candidate COVID-19 vaccines for children on their safety and immunogenicity and the impact of severe acute respiratory syndrome coronavirus 2 variants on childhood vaccination. Safety issues on pediatric vaccines post-approval, like adverse events following immunization and adverse events of special interest require studies on long-term and effective regulatory mechanisms.
