A cohort study of maternal pregnancy-related anxiety at different trimesters and infants′ neurobehavioral development
10.3760/cma.j.cn112150-20200713-00998
- VernacularTitle:孕期妊娠相关焦虑与婴幼儿神经行为发育关联的队列研究
- Author:
Shanshan SHAO
1
;
Kun HUANG
;
Shuangqin YAN
;
Peng ZHU
;
Jiahu HAO
;
Fangbiao TAO
Author Information
1. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系 出生人口健康教育部重点实验室 人口健康与优生安徽省重点实验室，合肥 230032
- Keywords:
Pregnant women;
Anxiety;
Cohort studies;
Neurobehavioral development;
Critical period
- From:
Chinese Journal of Preventive Medicine
2021;55(2):177-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the influence and critical period of pregnancy-related anxiety during pregnancy on the neurobehavioral development of infants.Methods:The subjects of this study were derived from the Ma′anshan Birth Corhot. From May 2013 to September 2014, a total of 3 474 pregnant women who registered in Ma ′anshan Maternal and Child Health Care Center were enrolled in the study. A total of 2 242 mother-infant pairs who completed three times assessments of maternal anxiety and at least once assessment of infants′ neurobehavioral development were included in the final analysis. Maternal pregnancy-related anxiety was assessed by the Pregnancy-Related Anxiety Questionnaire during the first, second and third trimesters of pregnancy. When their children were at 6 and 18 months, their neurobehavioral development was evaluated using the Ages & Stages Questionnaire-China. The influence of maternal pregnancy-related anxiety on the neurobehavioral development of infants was analyzed by bi-nominal logistic regression.Results:The age of 2 242 pregnant women was (26.62±3.65) years, and the proportion of boys, low birth weight and exclusive breastfeeding for 6 months was 50% (1 120/2 242), 1.7% (38/2 242) and 11.5% (252/2 191), respectively. The detection rates of pregnancy-related anxiety during the first, second and third trimester were 24.9% (558), 28.6% (642) and 30.3% (674), respectively. After controlling confounding variables and other two trimester′s anxiety, only pregnancy-related anxiety during the third trimester (not first or second trimester) significantly increased the risk of developmental delay in the domain of communication (relative risk, RR = 3.52, 95% confidence interval, CI: 1.89-6.58) and personal-social ( RR=2.46, 95% CI: 1.10-5.49) at the 6 months of age, as well as in the domain of fine motor ( RR=2.07, 95% CI: 1.11-3.85), problem-solving domains ( RR=2.31, 95% CI: 1.24-4.31). Conclusion:Maternal pregnancy-related anxiety was associated with the risk of neurobehavioral development of infants, and the third trimester may be the critical period.
