Association of blood arsenic level with hyperuricemia among elderly aged 65 years and older in 9 longevity areas of China
10.3760/cma.j.cn112150-20200720-01028
- VernacularTitle:中国9个长寿地区65岁及以上人群血砷水平与高尿酸血症的关联研究
- Author:
Chengcheng LI
1
;
Yuebin LYU
;
Chen CHEN
;
Xiaochang ZHANG
;
Junfang CAI
;
Jinhui ZHOU
;
Heng GU
;
Zhaojin CAO
;
Feng ZHAO
;
Feng LU
;
Yingchun LIU
;
Xiaoming SHI
Author Information
1. 中国疾病预防控制中心环境与人群健康重点实验室 中国疾病预防控制中心环境与健康相关产品安全所，北京 100021
- Keywords:
Elderly;
Blood arsenic;
Hyperuricemia;
Heavy metals
- From:
Chinese Journal of Preventive Medicine
2021;55(1):60-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of blood arsenic level with hyperuricemia among elderly aged 65 years and older.Methods:Data was collected in 9 longevity areas from Heathy Aging and Biomarkers Cohort Study between 2017 and 2018. 2 438 participants aged 65 years and older with complete information on blood arsenic and uric acid were included in this study. Information including demographics characteristic, life style and health status was collected by questionnaire and physical examination. Meanwhile, venous blood was collected to detect the levels of blood arsenic and uric acid. Subjects were stratified into three groups (low, middle and high) by tertiles of blood arsenic level. Logistic regression models were used to analyze the association of blood arsenic level with hyperuricemia.Results:The age of participants was (84.57±11.41) years, of which 1 172 (48.07%) were male and 1 525 (62.55%) were over 80 years old. The detection rate of hyperuricemia was 17.23% (420), and the detection rates of hyperuricemia were 11.77%, 19.25% and 20.62% among participants with low, middle and high blood arsenic, respectively ( P<0.001). After controlling confounding factors, compared with participants who had low blood arsenic, the ORs (95% CI) of hyperuricemia for the participants with middle and high blood arsenic were 1.57 (1.12-2.23) and 2.08 (1.46-2.99), respectively. Subgroups analysis showed that compared with female, the association between blood arsenic level and hyperuricemia was more obvious in males ( Pinteraction<0.05). Conclusion:Blood arsenic level is associated with the risk for hyperuricemia among the elderly aged 65 years and older in 9 longevity areas in China.
