Research progress of relationship between vitamin K and type 2 diabetes
10.3760/cma.j.cn112150-20190520-00407
- VernacularTitle:维生素K与2型糖尿病关系的研究进展
- Author:
Anlan CAO
1
;
Yuwei LAI
;
Henggui CHEN
;
Liting SHENG
;
An PAN
Author Information
1. 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系武汉 430030
- Keywords:
Vitamin K;
Diabetes mellitus, type 2;
Review
- From:
Chinese Journal of Preventive Medicine
2020;54(5):555-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically review research on the association between vitamin K and type 2 diabetes and diabetes-related biomarkers in humans, and evaluate the role of vitamin K in the prevention of type 2 diabetes.Methods:"Vitamin K", "type 2 diabetes" and related terms were searched in PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang Med Online up to November 2018.Results:A total of 1 Chinese and 12 English articles were included. Among 6 observational studies, 5 of them showed that higher dietary vitamin K intake and plasma vitamin K level were associated with the decrease of the risk of type 2 diabetes. Among 6 clinical intervention studies, 5 of them indicated that the supplementation of vitamin K 1 or K2 could have positive influence on insulin metabolism. One Mendelian randomization study showed higher circulation vitamin K level might reduce the risk of type 2 diabetes. Conclusion:Vitamin K plays an important role in the prevention and control of type 2 diabetes, which may be related to the improvement of insulin metabolism and blood glucose level.
