Research progress of curcumin in the treatment of osteoarthritis
10.3760/cma.j.cn112139-20210127-00055
- VernacularTitle:姜黄素治疗骨关节炎的研究进展
- Author:
Xianyue SHEN
1
;
Yang LI
;
Zhuo ZHANG
Author Information
1. 吉林大学中日联医院骨关节外科，长春130031
- Keywords:
Osteoarthritis;
Molecular mechanisms of pharmacological action;
Curcumin
- From:
Chinese Journal of Surgery
2021;59(6):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Curcumin is the main active component of Curcuma longa,which has a variety of biological activities and pharmacological properties.Clinical studies have shown that curcumin and its derivatives can improve the pathological progress of osteoarthritis. The mechanism mainly includes enhancing the activity of antioxidant enzymes,inhibiting oxidative stress,and protecting cartilage from damage;blocking inflammation-related signal pathways,reducing the production and activity of inflammatory factors,and reducing inflammation;playing the role of immune regulation by interacting with immune cells and immune molecules;slowing down osteoarthritis by inhibiting chondrocyte apoptosis and enhancing cartilage protection. Curcumin is one of the potential drugs for the treatment of osteoarthritis.
