The research progress in clinicopathological characteristics and treatment of hepatitis B virus-associated intrahepatic cholangiocarcinoma
10.3760/cma.j.cn112139-20200123-00046
- VernacularTitle:重视乙肝病毒相关性肝内胆管癌的临床病理学特征及治疗方法
- Author:
Zhaohui TANG
1
;
Huanjun TONG
;
Zhiwei QUAN
Author Information
1. 上海交通大学医学院附属新华医院普通外科 200092
- Keywords:
Biliary tract neoplasms;
Hepatitis B virus;
Clinicopathological characteristics;
Treatment
- From:
Chinese Journal of Surgery
2020;58(4):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B is a common and multiplex disease in China. Recently, epidemiological studies have shown that hepatitis B virus(HBV) infection is a high-risk factor for the development of intrahepatic cholangiocarcinoma(ICC). Based on a retrospective analysis of relevant literature of recent years, this article concludes that HBV-associated ICC is very different from other ICC regarding clinicopathological characteristics and treatment. Distinctive features of patients with HBV-associated ICC included younger age, preponderance of male patients, frequent elevation of alpha fetoprotein, decrease of CA19-9, frequent appearance of cirrhosis, infrequent lymph node metastasis and better prognosis. Because these clinicopathological features are similar to those of HBV-associated hepatocellular carcinoma(HCC), we speculate that the cell origin of HBV-associated ICC and HBV-associated HCC are consistent. In addition, this article also discusses that HBV-associated ICC should be treated with surgery-based comprehensive treatment in order to improve prognosis.
