Trends, challenges, and reflections on early-onset gastric cancer
10.3760/cma.j.cn441530-20240329-00117
- VernacularTitle:早发性胃癌的发病趋势和治疗挑战及其未来思考
- Author:
Xuefei WANG
1
;
Yihong SUN
Author Information
1. 复旦大学附属中山医院普通外科，上海 200032
- Keywords:
Stomach neoplasms, early-onset;
Treatment;
Tendency;
Challenge
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(5):425-429
- CountryChina
- Language:Chinese
-
Abstract:
Early onset gastric cancer (EOGC), as a distinct type of gastric cancer, has seen a gradually increasing incidence in recent years, imposing significant negative impacts on society and families, and has attracted widespread attention. EOGC presents a series of clinical characteristics, such as a higher prevalence among women, pathological types predominantly being poorly differentiated or undifferentiated, and Lauren classification often being diffuse, making it more prone to distant metastasis. However, the causes and mechanisms of its onset are not yet fully understood. Notably, about 10% of EOGC cases exhibit familial clustering and germline mutations in the Cadherin-1 (CDH1) or α-1 catenin (CTNNA1) genes, known as hereditary diffuse gastric cancer (HDGC). These unique clinical features pose significant challenges for the diagnosis and treatment of EOGC. The core of treatment for early onset gastric cancer focuses on strong efficacy, function preservation, rehabilitation, and social reintegration. Clinically, a multidisciplinary approach and comprehensive treatment are essential, with equal emphasis on physiological and psychological aspects, balancing therapeutic effectiveness with functional outcomes, to benefit more patients with EOGC.
