Recurrence pattern of pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer
10.3760/cma.j.cn441530-20240125-00042
- VernacularTitle:局部进展期直肠癌新辅助放化疗后病理完全缓解的复发模式
- Author:
Zhigang SUN
1
;
Haizeng ZHANG
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院结直肠外科，北京 100021
- Keywords:
Rectal neoplasms, locally advanced;
Neoadjuvant chemoradiotherapy;
Pathological complete response;
Recurrence pattern
- From:
Chinese Journal of Gastrointestinal Surgery
2024;27(4):365-371
- CountryChina
- Language:Chinese
-
Abstract:
Patients with locally advanced rectal cancer who undergo neoadjuvant chemoradiotherapy may achieve pathological complete response (pCR). The incidence of recurrence is low among patients with pCR, there is still a lack of consensus on postoperative treatment and follow-up strategy. This review summarizes the recurrence patterns of patients with pCR, including distant metastasis rate, characteristics of distant metastasis time and location, local recurrence rate, and local recurrence time. The aim is to provide reference for the postoperative treatment and follow-up strategy of patients with pCR. Patients with pCR have a low recurrence rate, with infrequent local recurrence. Distant metastasis is the most common recurrence pattern, primarily in the lung and secondly in the regional lymph node. The time of recurrence is delayed which suggests the need for appropriate adjustments to follow-up strategy, extending the follow-up period, and placing emphasis on monitoring sites prone to recurrence.
