Radiation-induced intestinal fibrosis: pathological assessment and pharmacological prevention
10.3760/cma.j.cn441530-20230816-00050
- VernacularTitle:放射性肠纤维化的病理学评估与药物预防
- Author:
Zhifen CHEN
1
;
Zhun LIU
Author Information
1. 福建医科大学附属协和医院结直肠外科，福州 350001
- Keywords:
Radiation-induced intestinal fibrosis;
Diagnosis;
Pathological assessment;
Pharmacological prevention
- From:
Chinese Journal of Gastrointestinal Surgery
2023;26(10):935-939
- CountryChina
- Language:Chinese
-
Abstract:
Although radiotherapy can improve the local control rate of tumors and prolong the survival period of patients, it can also lead to long-term adverse effects such as radiation-induced intestinal fibrosis. Radiation-induced intestinal fibrosis has a high incidence and poses significant challenges to treatment, severely impacting the quality of life of patients. Combining findings from domestic and international research, along with experiences of our center, this article mainly discusses the pathological changes of radiation-induced intestinal fibrosis, as well as the current status and challenges of pathological assessment and pharmacological prevention of this condition. At present, there is no definitive method to reverse the fibrotic pathological changes. Thus, the prevention of fibrosis is a crucial issue to be resolved. In the meantime, there is a lack of ideal assessment methods and effective preventive medications in clinical practice. It is necessary to enhance both basic and clinical research, thoroughly investigate the pathogenesis of the disease, and identify effective intervention targets to promote the diagnosis and treatment of radiation-induced intestinal fibrosis.
