Expressions of Notch signaling-associated proteins in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1671-0274.2015.09.015
- VernacularTitle:Notch信号通路相关蛋白在食管鳞状细胞癌中的表达
- Author:
Yong YUAN
1
;
Yang HU
;
Yongfan ZHAO
;
Longqi CHEN
Author Information
1. 四川大学华西医院胸外科
- Keywords:
Esophageal neoplasms,squamous cell carcinoma;
Notch signaling;
Ki-67 index;
Immunohistochemistry
- From:
Chinese Journal of Gastrointestinal Surgery
2015;(9):909-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and the role of Notch signaling-associated proteins in esophageal squamous cell carcinoma (ESCC). Methods Fifty patients with ESCC were included in this study. The expressions of Notch signaling-associated protein (4 receptors: Notch1, Notch2, Notch3, Notch4; 5 ligands: Dll1, Dll3, Dll4, Jagged1, Jagged2) in cancer foci and adjacent normal tissues (5 cm distance to cancer) were examined by immunohistochemitry. Correlations of these proteins with cancer cell proliferation ( Ki-67 index ) and clinicopathologic features were investigated . Results Higher levels of Notch1 and Notch2 were measured in cancer foci compared with adjacent tissues (all P<0.05). There were no differences in the expressions of Notch3, Dll1 and Dll3 (all P>0.05). Notch4, Dll4 and Jagged2 were not detected in both cancer foci and adjacent tissues. Notch1 expression was negatively correlated with lymph node metastasis and TNM staging (all P<0.01). Jagged 1 expression was positively correlated with TNM staging (P<0.01). Ki-67 index was obviously higher in cancer foci, while it was negatively correlated with Notch1 and Notch3 (all P<0.01) and positively correlated with Dll1 and Jagged 1 (all P<0.01). Conclusion Notch signaling path may act as tumor suppressive gene in the pathogenesis of esophageal squamous cell cancer , in which Notch1 protein plays an important role.
