Research progress of lidocaine in the treatment of cancer pain
- VernacularTitle:利多卡因治疗癌性疼痛研究进展
- Author:
Kairun ZHU
1
;
Chenglan XIE
;
Xiaoqian YANG
;
Wenjie JIN
Author Information
- Keywords: cancer pain; types of cancer pain; mechanism; lidocaine; opioids
- From: Journal of Clinical Medicine in Practice 2023;27(22):131-137
- CountryChina
- Language:Chinese
- Abstract: Pain permeates the entire process of cancer,and its mechanism is complex,involving tumor microenvironment,cancer-related bone pain,cancer-related visceral pain,cancer-related neuro-pathic pain,and surgery and radiotherapy-related factors.Studies have indicated that lidocaine can al-leviate intractable cancer pain for opioids,and its mechanism of action in treating various types of cancer pain may also be different,involving the regulation of acid-sensing ion channels(ASICS),transient receptor potential channels(TRP),voltage-gated sodium channels(VGSCs),nerve growth factor(NGF),glutamate and its receptors,inflammatory cells and cytokines,microglia,astrocytes,and high mobility group box 1 protein(HMGB1).This paper reviewed the mechanisms of cancer pain,the mechanisms of lidocaine in treating different types of cancer pain as well as its clinical appli-cations.
