Expression and clinical significance of PDCD4 and MMP-7 protein in human gastric carcinoma
- VernacularTitle:PDCD4与MMP-7在胃癌组织中的表达及临床意义
- Author:
Jianbo XI
1
;
Jianjun TANG
;
Zhenzhong FA
;
Zhengyu MING
Author Information
- Keywords: matrix metalloproteinases-7; programmed cell death 4; gastric cancer
- From: Journal of Clinical Medicine in Practice 2017;21(24):19-22
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expression and significance of PDCD4 and MMP-7 in human gastric carcinoma (GC) tissues and to analyze their association with clinical pathological characteristics in GC patients.Methods Immunohistochemical staining SP was used to detect the expression of PDCD4 and MMP-7 protein in gastric cancer specimens and para-carcinoma tissue in 70 cases,and the relationship with clinical pathological characteristics were analyzed.Results The expression rate of MMP-7 in GC tissues in the study group was high and significantly higher than that in the control group (78.6％ vs.22.9％,P ＜ 0.05),while the expression rate of PDCD4 protein was low and significantly lower than that in the control group (31.4％ vs.75.7％,P ＜0.05).Both the expressions of PDCD4 and MMP-7 were significantly associated with tumor lymph node metastasis,peritoneal metastasis,the depth of invasion and late clinical stage of GC (P(0.05).The correlation analysis indicated that there was a negative correlation between the expressions of PDCD4 and MMP-7 (r =-0.526,P =0.000).Conclusion The expression of PDCD4 and MMP-7 might be correlated to the carcinogenesis and invasion,and might be involved in the GC regulation.
