Effect of edaravone combined with statins on serum homocysteine, C-reactive protein and lipid levels in patients with ischemic stroke
10.7619/jcmp.201719008
- VernacularTitle:依达拉奉联合他汀类药物对缺血性脑卒中患者血清同型半胱氨酸、C反应蛋白、血脂水平的影响
- Author:
Yunnan LU
1
;
Ye HUA
;
Zhiqiang FENG
;
Tao MA
;
Peicheng HE
;
Shuangshuang WU
;
Hong XU
Author Information
1. 南京医科大学附属无锡市第二人民医院神经内科
- Keywords:
ischemic stroke;
edaravone;
homocysteine;
C-reactive protein;
prognosis
- From:
Journal of Clinical Medicine in Practice
2017;21(19):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of edaravone combined with statins on levels of serum homocysteine (Hcy),C-reactive protein (CRP) and total cholesterol (TC),triglyceride (TG),high-density lipoprotein HDL),low-density lipoprotein cholesterol (LDL-C) in patients with ischemic stroke.Methods A total of 63 patients with ischemic stroke in our hospital were divided into two groups,27 cases in control group were given atorvastatin,and 36 patients in the observation group were given edaravone treatment in addition.The levels of Hcy,TG,TC,HDL and low LDL-C were detected.At the same time,stroke scale of NIHSS,Barthel index of daily living ability,Self Anxiety Scale (SAS) and Self Depression Scale (SDS) were recorded at 14 days before and after treatment.Results The observation group had lower Hcy,CRP and LDL-C levels,while higher HDL level.Total effective rate in the observation group was significantly higher than the control group (88.89％ vs.77.78％,P ＜0.05).The observation group had higher Barthel index and lower SAS,SDS scores than the control group (P ＜ 0.05).Conclusion Edaravone combined with atorvastatin can significantly improve patients' treatment outcomes,and improve prognosis and life ability.
