Influence of chemotherapy on the changes of tumor markers levels in patients with advanced lung cancer
10.7619/jcmp.201713008
- VernacularTitle:化疗对晚期肺癌患者肿瘤标志物水平变化的影响
- Author:
Tianming CHEN
1
;
Guohui YU
;
Renxiang LI
;
Qing LU
Author Information
1. 湖北省荆门市第一人民医院 呼吸内科
- Keywords:
chemotherapy;
patients with advanced lung cancer;
levels of tumor markers
- From:
Journal of Clinical Medicine in Practice
2017;21(13):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of chemotherapy on the changes of tumor markers levels in patients with advanced lung cancer.Methods A total of 75 patients with advanced lung cancer were selected amd treated with the combination of two drugs based on platinum.The therapeutic effect was judged by the changes of solid tumor according to medical image.The levels of tumor markers before and after the treatment were tested by chemiluminescence immunoassay,and tumor markers including cancer embryonic antigen(CEA),neuron specific enolase(NSE),carbohydrate antigen 125(CA125),cytokeratin(CYFRA211),squamous cell cancer antigen(SCC).Results The levels of tumor markers were significantly lower after the treatment than those before the treatment(P<0.05).The decreased level of patients with CR and PR were significantly lower than those with SD and PD(P<0.05).There was significant difference in the changes of tumor markers levels before and after treatment between the patients with different tumor types.Conclusion Effective chemotherapy can significantly decrease the levels of tumor markers in patients with advanced lung cancer.
