Relationship between the serum high mobility group box-1 protein, prostaglandin E2, vasculaRendothelial growth factor, interleukin and acute lymphoblastic leukemia
10.7619/jcmp.201709011
- VernacularTitle:血清高迁移率族蛋白1、前列腺素E2、血管内皮生长因子及白介素与急性淋巴细胞白血病的关系
- Author:
Yimin HU
1
;
Shangzhu LI
Author Information
1. 中国医学科学院血液病医院综合诊疗中心 内科
- Keywords:
serum;
high mobility group box-1 protein;
prostaglandin E2;
vasculaRendothelial growth factor;
interleukin;
acute lymphoblastic leukemia
- From:
Journal of Clinical Medicine in Practice
2017;21(9):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the serum high mobility group box-1 protein (HMGB1),prostaglandin E2 (PGE2),vasculaRendothelial growth factoR(VEGF),interleukin (IL) and acute lymphoblastic leukemia.Methods A total of 68 patients with acute lymphoblastic leukemia were selected as observation group,and 68 healthy people at the same time were selected as control group.The serum HMGB1,PGE2,VEGF and IL levels of two groups were detected and compared,the serum detection results of patients with different stages and types of acute lymphoblastic leukemia were compared in the observation group,and the relationship between those serum indexes and acute lymphoblastic leukemia was analyzed by the Logistic analysis.Results The serum HMGB1,PGE2,VEGF and IL levels of observation group were significantly higheRthan those of the control group,and the serum detection results of patients with different stages and types of acute lymphoblastic leukemia had significant differences in the observation group.Logistic analysis showed that the serum HMGB1,PGE2,VEGF and IL were closely correlated with acute lymphoblastic leukemia (P<0.05).Conclusion The serum HMGB1,PGE2,VEGF and IL of patients with acute lymphoblastic leukemia are in high expression state,and there are significant differences in patients with different stages and types.
