Clinical effects of low molecular heparin calcium on N-terminal pro-brain natriuretic peptide and blood plasma D-dipolymer level in heart failure patients with pulmonary heart disease
10.7619/jcmp.201417003
- VernacularTitle:低分子肝素钙对肺源性心脏病心力衰竭患者临床疗效及血浆N-末端脑钠肽前体、D-二聚体水平的影响
- Author:
Zhengrong XI
1
;
Xin HU
;
Wenbing LIU
Author Information
1. 江苏省南通市妇幼保健医院 呼吸内科
- Keywords:
pulmonary heart disease;
heart failure;
low molecular heparin calcium;
hemorheology;
N-terminal pro-brain natriuretic peptide;
blood plasma D-dipolymey;
thrombus
- From:
Journal of Clinical Medicine in Practice
2014;(17):8-11
- CountryChina
- Language:Chinese
-
Abstract:
Obj ective To observe the clinical effects of low molecular heparin calcium on hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.Methods 95 heart failure patients with pulmonary heart disease were randomly divided into observation (n= 45 )and control groups (n= 50),both treated with regular treatment.Extra hypodermic injection of low molecular heparin calcium was given to observation group.Clinical effects,adverse events,hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipolymer (D-D)level were observed.Results Effective rate in observation group (95 .56%)was significantly higher than in control group (82.00%)(P<0.05),and significant difference was found in adverse events. Hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level were improved in both groups after treatment (P<0.05,P<0.01),and differ-ences between 2 groups were significant (P<0.05,P<0.01).Conclusion Low molecular hep-arin calcium combined with dobutamine and magnesium sulfate has the potential to improve the hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.
