Effects of desloratadine on the levels of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rats model
10.7619/jcmp.201416032
- VernacularTitle:地氯雷他定对过敏性哮喘豚鼠模型肺泡灌洗液IL-4和 IL-13水平的影响
- Author:
Li ZHANG
1
;
Ruqin BAI
;
Lihao BAI
Author Information
1. 江苏省南京市胸科医院
- Keywords:
desloratadine;
allergic asthma;
rats;
bronchoalveolar lavage fluid;
IL-4;
IL-13
- From:
Journal of Clinical Medicine in Practice
2014;(16):105-106,111
- CountryChina
- Language:Chinese
-
Abstract:
Objective 5BTo study the effects of desloratadine on the level of IL-4 and IL-13 in bronchoalveolar lavage fluid of allergic asthmatic rat model.Methods The allergic asthmatic rat model was induced by ovalbumin.Then the effects of desloratadine on the latent period of asth-ma,the level of IL-4 and IL-13 in bronchoalveolar lavage fluid were observed.Results Deslorata-dine could extend the latent period of asthma,and decrease the level of IL-4 and IL-13 in bron-choalveolar lavage fluid.Conclusion Desloratadine could delay the onset of asthma by decreasing the level of IL-4 and IL-13.So it provides basis for the clinical use in treating asthma.
