Effects of biomaterials on the inflammatory response in tissue-engineered cartilage
10.3760/cma.j.cn114453-20230928-00065
- VernacularTitle:组织工程软骨中生物材料对炎症反应的影响
- Author:
Yanlong YANG
1
;
Haiyue JIANG
Author Information
1. 中国医学科学院北京协和医学院整形外科医院外耳整形再造中心，北京 100144
- Keywords:
Tissue engineering;
Cartilage;
Inflammation;
Biomaterials
- From:
Chinese Journal of Plastic Surgery
2024;40(8):819-824
- CountryChina
- Language:Chinese
-
Abstract:
Cartilage tissue engineering offers a promising therapeutic approach for auricular, tracheal, and joint reconstruction. However, implanted engineered cartilage currently faces challenges such as host immune rejection and inflammatory reactions, which can lead to deformities and fibrosis, compromising long-term maintenance of shape and function. Effectively modulating immune and inflammatory responses is crucial for advancing the clinical application of engineered cartilage. This article reviewed relevant literature to analyze the mechanisms of inflammatory responses occurring after the implantation of tissue-engineered cartilage, and summarized the types and surface characteristics of biomaterials, providing a reference for the design of biomaterials in cartilage tissue engineering.
