Research progress of mesenchymal stem cell-derived exosomes in hair regeneration

VernacularTitle:间充质干细胞来源外泌体在毛发再生中的研究进展
Author: Wanjun ZHANG ¹ ; Peihua ZHANG
Author Information

1. 广东医科大学附属医院整形外科，湛江　524000
Keywords: Mesenchymal stem cells; Exosome; Dermal papilla cells; Hair follicles
From: Chinese Journal of Plastic Surgery 2024;40(1):112-117
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSCs) are a type of adult stem cells derived from the mesoderm, with the ability for self-renewal and multidirectional differentiation. Mesenchymal stem cell-derived exosomes (MSCs-Exo) are bioactive extracellular vesicles secreted by various MSCs into body fluids. They offer advantages such as anti-inflammatory properties, tissue repair, promotion of cell proliferation and differentiation, and regulation of the hair growth cycle. Hair regeneration involves the interaction of various cells and cytokines. Dermal papilla cells (DPCs) are considered as a unique MSCs with the functional properties of autologous stem cells. As the signaling center of the hair follicle, it plays an important role in regulating hair growth. MSCs-Exo can promote the proliferation and differentiation of DPCs by regulating the hair growth cycle. In recent years, research on MSCs-Exo has provided a new strategy for hair regeneration. This article reviewed the research on the use of MSCs-Exo for hair regeneration, aiming to offer new insights for the treatment of alopecia.