Research progress of nuclear factor E2-related factor 2 signaling pathway in pathological scar
10.3760/cma.j.cn114453-20221021-00330
- VernacularTitle:核因子E2相关因子2信号通路在病理性瘢痕中作用的研究进展
- Author:
Ling GONG
1
;
Yu LI
;
Juan MA
;
Hongyu CHI
;
Xianglin DONG
Author Information
1. 新疆医科大学第一附属医院整形科，乌鲁木齐 830011
- Keywords:
Cicatrix, hypertrophic;
Keloid;
Nuclear factor E2-related factor signaling pathway;
Reactive oxygen species;
Pathological scar;
Wound healing
- From:
Chinese Journal of Plastic Surgery
2023;39(11):1167-1172
- CountryChina
- Language:Chinese
-
Abstract:
Nuclear factor E2-related factor 2 (Nrf2) is a major regulator of redox homeostasis in cells, and Nrf2 signaling pathway has anti-inflammatory, anti-oxidative stress, and anti-fibrosis effects and plays an important role in wound healing and pathological scar formation and progression. This article reviewed the related research on the effect of oxidative stress and Nrf2 signaling pathway on pathological scars, and expounded the relationship between Nrf2 signaling pathway, oxidative stress and pathological scars, providing a new perspective for the mechanism study and clinical prevention and treatment of pathological scars.
